identical pH [Dissolution / BCS / IVIVC]

posted by Helmut Homepage – Vienna, Austria, 2019-09-10 10:58 (643 d 18:24 ago) – Posting: # 20571
Views: 4,586

Hi amer,

» I have constructed IVIVC using in vivo data and dissolution data done at pH 1.2. if i have a new dissolution data (say done at pH 2), how can i predict the in vivo concentrations based on the new dissolution…

[image]Dissolution at pH 2 is rather unusual. Recall the definition: pH = –log10[H+], where [H+] is the [image] activity of the H+ ion. Hence, at pH 2 you have 10–2/10–1.2 ~ 6.31× lower activity of H+ than at pH 1.2. Whether this is relevant, depends on the pKa of the drug. However, it might lead to wrong conclusions.

Valid predictions based on IVIVC require dissolution at identical pH values. Repeat the exercise at pH 1.2.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,518 posts in 4,498 threads, 1,524 registered users;
online 22 (0 registered, 22 guests [including 6 identified bots]).
Forum time: Tuesday 05:22 CEST (Europe/Vienna)

I suppose it is tempting, if the only tool you have is a hammer,
to treat everything as if it were a nail.    Abraham Maslow

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5