Assumptions… [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2019-09-09 14:09  – Posting: # 20558
Views: 1,370

Hi Rocco,

see what I wrote above.
Since you have no idea about the new formulation you have to assume indeed that the variances of T and R are at least similar. If you don’t like this assumption, there are just two ways out:
  1. Pilot study or
  2. Adaptive Two-Stage Sequential design.
Even if you are wary and walk this road, you have to assume things. The CV and the T/R-ratio are estimates and therefore, uncertain. Relying on assumptions is part of the game. Only death is certain.

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
20,138 posts in 4,246 threads, 1,387 registered users;
online 4 (0 registered, 4 guests [including 4 identified bots]).
Forum time (Europe/Vienna): 23:39 CET

The fundamental cause of trouble in the world today is
that the stupid are cocksure
while the intelligent are full of doubt.    Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5