Assumptions… [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2019-09-09 12:09  – Posting: # 20558
Views: 1,547

Hi Rocco,

see what I wrote above.
Since you have no idea about the new formulation you have to assume indeed that the variances of T and R are at least similar. If you don’t like this assumption, there are just two ways out:
  1. Pilot study or
  2. Adaptive Two-Stage Sequential design.
Even if you are wary and walk this road, you have to assume things. The CV and the T/R-ratio are estimates and therefore, uncertain. Relying on assumptions is part of the game. Only death is certain.

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
20,237 posts in 4,258 threads, 1,396 registered users;
online 3 (0 registered, 3 guests [including 2 identified bots]).
Forum time (Europe/Vienna): 23:46 UTC

Nothing shocks me. I’m a scientist.    Harrison Ford (as Indiana Jones)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5