Assumptions… [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2019-09-09 14:09 (496 d 15:15 ago) – Posting: # 20558
Views: 3,761

Hi Rocco,

see what I wrote above.
Since you have no idea about the new formulation you have to assume indeed that the variances of T and R are at least similar. If you don’t like this assumption, there are just two ways out:
  1. Pilot study or
  2. Adaptive Two-Stage Sequential design.
Even if you are wary and walk this road, you have to assume things. The CV and the T/R-ratio are estimates and therefore, uncertain. Relying on assumptions is part of the game. Only death is certain.

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,303 posts in 4,441 threads, 1,487 registered users;
online 5 (0 registered, 5 guests [including 3 identified bots]).
Forum time: Monday 04:24 CET (Europe/Vienna)

I believe there is no philosophical high-road in science,
with epistemological signposts. No, we are in a jungle
and find our way by trial and error,
building our road behind us as we proceed.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5