predicting in vivo PK profiles from in vitro data after establishing IVIVC [Dissolution / BCS / IVIVC]

posted by amer – Australia, 2019-09-09 05:04 (873 d 10:51 ago) – Posting: # 20555
Views: 5,845

I have conducted IVIVC analysis using the IVIVC for R package, all good!

Now that I have estabished IVIVC levy plots (and regression equation); how can i predict the plasma concentrations profile if i have got a new in vitro dissolution profile (not used to establish ivivc) for the same formulation done in a different dissolution media? (i.e going backwards)

For the new dissolution data (not used to establish ivivc), i can calulate the predicted fraction absorbed using the regression equation from the constructed IVIVC. But then, how can i predict the in vivo plasma Pk profile from the predicted fraction absorbed? does the ivivc for R package do that? how? what is the r-script that i can use.

I am using R studio.


Complete thread:

 Admin contact
21,858 posts in 4,574 threads, 1,554 registered users;
online 24 (0 registered, 24 guests [including 16 identified bots]).
Forum time: Saturday 14:55 CET (Europe/Vienna)

Truth in science can be defined as the working hypothesis best suited
to open the way to the next better one.    Konrad Lorenz

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz