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Registerpredicting in vivo PK profiles from in vitro data after establishing IVIVC [Dissolution / BCS / IVIVC]
I have conducted IVIVC analysis using the IVIVC for R package, all good!
Now that I have estabished IVIVC levy plots (and regression equation); how can i predict the plasma concentrations profile if i have got a new in vitro dissolution profile (not used to establish ivivc) for the same formulation done in a different dissolution media? (i.e going backwards)
For the new dissolution data (not used to establish ivivc), i can calulate the predicted fraction absorbed using the regression equation from the constructed IVIVC. But then, how can i predict the in vivo plasma Pk profile from the predicted fraction absorbed? does the ivivc for R package do that? how? what is the r-script that i can use.
I am using R studio.
Thanks,
Now that I have estabished IVIVC levy plots (and regression equation); how can i predict the plasma concentrations profile if i have got a new in vitro dissolution profile (not used to establish ivivc) for the same formulation done in a different dissolution media? (i.e going backwards)
For the new dissolution data (not used to establish ivivc), i can calulate the predicted fraction absorbed using the regression equation from the constructed IVIVC. But then, how can i predict the in vivo plasma Pk profile from the predicted fraction absorbed? does the ivivc for R package do that? how? what is the r-script that i can use.
I am using R studio.
Thanks,
Complete thread:
- predicting in vivo PK profiles from in vitro data after establishing IVIVCamer 2019-09-09 05:04 [Dissolution / BCS / IVIVC]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- external predictability for ivivc yjlee168 2019-09-09 10:46
- external predictability for ivivc amer 2019-09-10 02:31
- identical pH Helmut 2019-09-10 10:58
- identical pH yjlee168 2019-09-10 15:30
- R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
- Software validation, another round Helmut 2019-09-10 15:37
- Deconvolution mittyri 2019-09-10 15:54
- Software validation, another round yjlee168 2019-09-11 10:29
- Software validation, another round Helmut 2019-09-11 13:39
- Software validation, another round amer 2019-09-12 05:26
- Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
- Who inspects the inspectors? Helmut 2019-09-13 12:07
- Who inspects the inspectors? nobody 2019-09-13 12:55
- Sapienti sat Helmut 2019-09-13 12:59
- Who inspects the inspectors? nobody 2019-09-13 12:55
- Who inspects the inspectors? Helmut 2019-09-13 12:07
- Should we also consider to validate the validation? yjlee168 2019-09-12 09:46
- Software validation, another round amer 2019-09-12 05:26
- Software validation, another round Helmut 2019-09-11 13:39
- R scripts/codes for in-vivo conc. amer 2019-09-11 05:35
- Bioavailabity term in predicted in-vivo conc. yjlee168 2019-09-11 10:16
- Software validation, another round Helmut 2019-09-10 15:37
- identical pH Helmut 2019-09-10 10:58
- external predictability for ivivc amer 2019-09-10 02:31
- external predictability for ivivc yjlee168 2019-09-09 10:46
Ing. Helmut Schütz