Bioequivalence and Bioavailability Forum • transit compartments...

transit compartments... [PK / PD]

posted by mittyri – Russia, 2019-09-08 00:25 (1922 d 16:17 ago) – Posting: # 20553
Views: 5,066

Hi Helmut,

❝ An idea: Parameterize models with rate-constants (instead of CL) and compare k_el of the IR formulation with k_a of the MR formulation. Are they similar?

as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...

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Kind regards,
Mittyri

Complete thread:

PK model parameters IR vs MR mittyri 2019-09-02 22:15 [PK / PD]
- PK model parameters IR vs MR jag009 2019-09-03 16:07
  - PK model parameters IR vs MR mittyri 2019-09-03 16:54
- PK model parameters IR vs MR ElMaestro 2019-09-03 17:43
  - PK model parameters IR vs MR mittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
  - transit compartments...mittyri 2019-09-07 22:25
    - No organs in (Pop)PK Helmut 2019-09-08 10:56