transit compartments... [PK / PD]

posted by mittyri – Russia, 2019-09-07 20:25 (538 d 01:44 ago) – Posting: # 20553
Views: 2,185

Hi Helmut,

» An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?

as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...

Kind regards,

Complete thread:

 Admin contact
21,357 posts in 4,459 threads, 1,492 registered users;
online 6 (0 registered, 6 guests [including 3 identified bots]).
Forum time: Friday 22:10 UTC (Europe/Vienna)

Those who make no mistakes are making the biggest mistakes of all 
they are attempting nothing new.    Anthony de Mello

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz