transit compartments... [PK / PD]

posted by mittyri – Russia, 2019-09-07 20:25 (447 d 08:44 ago) – Posting: # 20553
Views: 2,016

Hi Helmut,

» An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?

as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...

Kind regards,

Complete thread:

 Admin contact
21,215 posts in 4,427 threads, 1,482 registered users;
online 18 (0 registered, 18 guests [including 11 identified bots]).
Forum time: Saturday 05:10 UTC (Europe/Vienna)

Science may be described as the art of systematic over-simplification –
the art of discerning what we may with advantage omit.    Karl R. Popper

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz