transit compartments... [PK / PD]

posted by mittyri – Russia, 2019-09-07 22:25  – Posting: # 20553
Views: 840

Hi Helmut,

» An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?

as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...

Kind regards,
Mittyri

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