transit compartments... [PK / PD]

posted by mittyri  – Russia, 2019-09-08 00:25 (2123 d 13:36 ago) – Posting: # 20553
Views: 5,643

Hi Helmut,

❝ An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?


as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...

Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
23,425 posts in 4,928 threads, 1,679 registered users;
55 visitors (1 registered, 54 guests [including 14 identified bots]).
Forum time: 14:02 CEST (Europe/Vienna)

Fools with Tools Are Still Fools!    Anonymous

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5