Parameter-identifiability? [PK / PD]

posted by Helmut Homepage – Vienna, Austria, 2019-09-07 13:03  – Posting: # 20552
Views: 1,532

Hi mittyri,

» […] data from MD study for IR formulation […] another dataset (SD) […] but MR formulation. Trying to build the model you figure out that the parameters differ significantly (both Cl and V).
» What could be a reason of that observation?

Flip-flop PK? Rather the rule than an exception with MR formulations. You might run into parameter-identifiability issues. Unless you have data from an IV dose you don’t know what the true elimination is.
An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?

Dif-tor heh smusma 🖖
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

 Admin contact
20,793 posts in 4,353 threads, 1,445 registered users;
online 6 (0 registered, 6 guests [including 5 identified bots]).
Forum time: 11:27 CEST (Europe/Vienna)

In God we trust;
all others must bring data.    W. Edwards Deming

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz