PK model parameters IR vs MR [PK / PD]

posted by mittyri – Russia, 2019-09-03 18:05  – Posting: # 20536
Views: 826

Hi ElMaestro,

» You have a difference in the absorbed fraction from the two formulations which screws everything up.

could you please explain what is happening here? Does it mean that changes in absorbed fraction did significantly modified PK of the drug? Are there any examples for another drugs where it was already observed?

» » We know that the kidneys do not care about lineage of entity.
» What is meant with this term??

Well, nothing special. I mean clearance does not depend on the route of administration for particular drug (or type of formulation).

But it seems to me that due to low absorption rate by time unit the PK properties of the analyte could be closer to some low dose IR (where non-linear kinetics rules). Is that correct?

Kind regards,
Mittyri

Complete thread:

Activity
 Admin contact
20,138 posts in 4,246 threads, 1,388 registered users;
online 7 (0 registered, 7 guests [including 3 identified bots]).
Forum time (Europe/Vienna): 07:43 CET

It is better to debate a question without settling it
than to settle a question without debating it.    Joseph Joubert

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5