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RegisterPK model parameters IR vs MR [PK / PD]
Hi ElMaestro,
could you please explain what is happening here? Does it mean that changes in absorbed fraction did significantly modified PK of the drug? Are there any examples for another drugs where it was already observed?
Well, nothing special. I mean clearance does not depend on the route of administration for particular drug (or type of formulation).
But it seems to me that due to low absorption rate by time unit the PK properties of the analyte could be closer to some low dose IR (where non-linear kinetics rules). Is that correct?
❝ You have a difference in the absorbed fraction from the two formulations which screws everything up.
could you please explain what is happening here? Does it mean that changes in absorbed fraction did significantly modified PK of the drug? Are there any examples for another drugs where it was already observed?
❝ ❝ We know that the kidneys do not care about lineage of entity.
❝ What is meant with this term??
Well, nothing special. I mean clearance does not depend on the route of administration for particular drug (or type of formulation).
But it seems to me that due to low absorption rate by time unit the PK properties of the analyte could be closer to some low dose IR (where non-linear kinetics rules). Is that correct?
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Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- PK model parameters IR vs MR mittyri 2019-09-02 22:15 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- PK model parameters IR vs MR jag009 2019-09-03 16:07
- PK model parameters IR vs MR mittyri 2019-09-03 16:54
- PK model parameters IR vs MR ElMaestro 2019-09-03 17:43
- PK model parameters IR vs MRmittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
- transit compartments... mittyri 2019-09-07 22:25
- No organs in (Pop)PK Helmut 2019-09-08 10:56
- transit compartments... mittyri 2019-09-07 22:25
- PK model parameters IR vs MR jag009 2019-09-03 16:07
Ing. Helmut Schütz