PK model parameters IR vs MR [PK / PD]

posted by ElMaestro  – Belgium?, 2019-09-03 17:43 (412 d 13:55 ago) – Posting: # 20535
Views: 2,028

Hi mittyri,

» recently I got a question from my colleague and I didn't find good answer. Maybe you can help.
» Suppose there's a data from MD study for IR formulation and the model built is good enough for the data description.
» Now you get another dataset (SD) with the same analyte but MR formulation. Trying to build the model you figure out that the parameters differ significantly (both Cl and V).
» What could be a reason of that observation?

You have a difference in the absorbed fraction from the two formulations which screws everything up.


» We know that the kidneys do not care about lineage of entity.

What is meant with this term??

I could be wrong, but...

Best regards,
ElMaestro

R's base package has 274 reserved words and operators, along with 1761 functions. I can use 18 of them (about 14 of them properly). I believe this makes me the Donald Trump of programming.

Complete thread:

Activity
 Admin contact
21,164 posts in 4,410 threads, 1,476 registered users;
online 5 (1 registered, 4 guests [including 1 identified bots]).
Forum time: Tuesday 07:39 CEST (Europe/Vienna)

In theory, there is no difference between theory and practice.
But, in practice, there is.    Jan L.A. van de Snepscheut

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5