Log in
RegisterPK model parameters IR vs MR [PK / PD]
Hi mittyri,
You have a difference in the absorbed fraction from the two formulations which screws everything up.
What is meant with this term??
❝ recently I got a question from my colleague and I didn't find good answer. Maybe you can help.
❝ Suppose there's a data from MD study for IR formulation and the model built is good enough for the data description.
❝ Now you get another dataset (SD) with the same analyte but MR formulation. Trying to build the model you figure out that the parameters differ significantly (both Cl and V).
❝ What could be a reason of that observation?
You have a difference in the absorbed fraction from the two formulations which screws everything up.
❝ We know that the kidneys do not care about lineage of entity.
What is meant with this term??
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- PK model parameters IR vs MR mittyri 2019-09-02 22:15 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- PK model parameters IR vs MR jag009 2019-09-03 16:07
- PK model parameters IR vs MR mittyri 2019-09-03 16:54
- PK model parameters IR vs MRElMaestro 2019-09-03 17:43
- PK model parameters IR vs MR mittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
- transit compartments... mittyri 2019-09-07 22:25
- No organs in (Pop)PK Helmut 2019-09-08 10:56
- transit compartments... mittyri 2019-09-07 22:25
- PK model parameters IR vs MR jag009 2019-09-03 16:07
Ing. Helmut Schütz