PK model parameters IR vs MR [PK / PD]
Hi John,
No, MR AUC < IR AUC
more than 10 times
Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself
❝ 1) Is the MR equivalent to IR with respect to AUC?
No, MR AUC < IR AUC
❝ 2) How different is the Cl and V (V in particular)?
more than 10 times
❝ 3) how good is the model fit?
Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- PK model parameters IR vs MR mittyri 2019-09-02 22:15 [PK / PD]
- PK model parameters IR vs MR jag009 2019-09-03 16:07
- PK model parameters IR vs MRmittyri 2019-09-03 16:54
- PK model parameters IR vs MR ElMaestro 2019-09-03 17:43
- PK model parameters IR vs MR mittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
- transit compartments... mittyri 2019-09-07 22:25
- No organs in (Pop)PK Helmut 2019-09-08 10:56
- transit compartments... mittyri 2019-09-07 22:25
- PK model parameters IR vs MR jag009 2019-09-03 16:07