PK model parameters IR vs MR [PK / PD]

posted by mittyri – Russia, 2019-09-03 18:54 (1668 d 13:19 ago) – Posting: # 20534
Views: 3,806

Hi John,

❝ 1) Is the MR equivalent to IR with respect to AUC?


No, MR AUC < IR AUC

❝ 2) How different is the Cl and V (V in particular)?


more than 10 times

❝ 3) how good is the model fit?


Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself

Kind regards,
Mittyri

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