PK model parameters IR vs MR [PK / PD]

posted by mittyri – Russia, 2019-09-03 14:54  – Posting: # 20534
Views: 1,082

Hi John,

» 1) Is the MR equivalent to IR with respect to AUC?

No, MR AUC < IR AUC

» 2) How different is the Cl and V (V in particular)?

more than 10 times

» 3) how good is the model fit?

Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself

Kind regards,
Mittyri

Complete thread:

Activity
 Admin contact
20,345 posts in 4,273 threads, 1,402 registered users;
online 4 (0 registered, 4 guests [including 2 identified bots]).
Forum time (Europe/Vienna): 23:07 UTC

The internet gave us all the power of speech,
and what did we discover?
That victory goes to he who shouts the loudest,
and that reason does not sell.    Claire North

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5