PK model parameters IR vs MR [PK / PD]

posted by mittyri – Russia, 2019-09-03 16:54 (455 d 09:35 ago) – Posting: # 20534
Views: 2,106

Hi John,

» 1) Is the MR equivalent to IR with respect to AUC?

No, MR AUC < IR AUC

» 2) How different is the Cl and V (V in particular)?

more than 10 times

» 3) how good is the model fit?

Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself

Kind regards,
Mittyri

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