PK model parameters IR vs MR [PK / PD]

posted by mittyri  – Russia, 2019-09-03 18:54 (2082 d 10:16 ago) – Posting: # 20534
Views: 5,525

Hi John,

❝ 1) Is the MR equivalent to IR with respect to AUC?


No, MR AUC < IR AUC

❝ 2) How different is the Cl and V (V in particular)?


more than 10 times

❝ 3) how good is the model fit?


Internally validated with another piece of data. CV is less than 20% for all parameters
Tried to use IR params for MR dataset, during convergence they are going away. The problem is not in the model fit by itself

Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
23,424 posts in 4,927 threads, 1,670 registered users;
152 visitors (0 registered, 152 guests [including 12 identified bots]).
Forum time: 05:10 CEST (Europe/Vienna)

By all means let’s be open-minded, but not so open-minded
that our brains drop out.    Richard Dawkins

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5