PK model parameters IR vs MR [PK / PD]

posted by mittyri – Russia, 2019-09-02 22:15  – Posting: # 20531
Views: 1,258

Dear All!

recently I got a question from my colleague and I didn't find good answer. Maybe you can help.
Suppose there's a data from MD study for IR formulation and the model built is good enough for the data description.
Now you get another dataset (SD) with the same analyte but MR formulation. Trying to build the model you figure out that the parameters differ significantly (both Cl and V).
What could be a reason of that observation?
We know that the kidneys do not care about lineage of entity.

Kind regards,
Mittyri

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