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RegisterPK model parameters IR vs MR [PK / PD]
Dear All!
recently I got a question from my colleague and I didn't find good answer. Maybe you can help.
Suppose there's a data from MD study for IR formulation and the model built is good enough for the data description.
Now you get another dataset (SD) with the same analyte but MR formulation. Trying to build the model you figure out that the parameters differ significantly (both Cl and V).
What could be a reason of that observation?
We know that the kidneys do not care about lineage of entity.
recently I got a question from my colleague and I didn't find good answer. Maybe you can help.
Suppose there's a data from MD study for IR formulation and the model built is good enough for the data description.
Now you get another dataset (SD) with the same analyte but MR formulation. Trying to build the model you figure out that the parameters differ significantly (both Cl and V).
What could be a reason of that observation?
We know that the kidneys do not care about lineage of entity.
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- PK model parameters IR vs MR mittyri 2019-09-02 22:15 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- PK model parameters IR vs MR jag009 2019-09-03 16:07
- PK model parameters IR vs MR mittyri 2019-09-03 16:54
- PK model parameters IR vs MR ElMaestro 2019-09-03 17:43
- PK model parameters IR vs MR mittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
- transit compartments... mittyri 2019-09-07 22:25
- No organs in (Pop)PK Helmut 2019-09-08 10:56
- transit compartments... mittyri 2019-09-07 22:25
- PK model parameters IR vs MR jag009 2019-09-03 16:07
Ing. Helmut Schütz