Outlier test for reference replicate crossover study design [Regulatives / Guidelines]

posted by abhimanyu – Banglore, 2019-08-13 15:11 (1092 d 06:41 ago) – Posting: # 20494
Views: 2,047

Hello Helmut/All,

I have question regarding outlier test (Using Lund's method) for reference replicate crossover study design.

How can we find outlier? which one will be appropriate scenario for any regulatory point of view?

Scenario 1 : can we use test and individual reference (R R) to calculate standardized residual?

Scenario 2 : Can we use test and average of reference (average of R R) to calculate standardized residual?




Thanks in advance!

Abhimanyu

Complete thread:

UA Flag
Activity
 Admin contact
22,289 posts in 4,666 threads, 1,585 registered users;
online 7 (0 registered, 7 guests [including 4 identified bots]).
Forum time: Tuesday 21:52 CEST (Europe/Vienna)

The existing scientific concepts cover always only
a very limited part of reality,
and the other part that has not yet
been understood is infinite.    Werner Heisenberg

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5