Outlier test for reference replicate crossover study design [Regulatives / Guidelines]

posted by abhimanyu – Banglore, 2019-08-13 15:11 (413 d 09:49 ago) – Posting: # 20494
Views: 1,625

Hello Helmut/All,

I have question regarding outlier test (Using Lund's method) for reference replicate crossover study design.

How can we find outlier? which one will be appropriate scenario for any regulatory point of view?

Scenario 1 : can we use test and individual reference (R R) to calculate standardized residual?

Scenario 2 : Can we use test and average of reference (average of R R) to calculate standardized residual?




Thanks in advance!

Abhimanyu

Complete thread:

Activity
 Admin contact
21,086 posts in 4,398 threads, 1,468 registered users;
online 2 (0 registered, 2 guests [including 1 identified bots]).
Forum time: Wednesday 01:00 CEST (Europe/Vienna)

When puzzled, it never hurts to read the primary documents 
a rather simple and self-evident principle that has, nonetheless,
completely disappeared from large sectors
of the American experience.    Stephen Jay Gould

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5