I love your subject line! [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2019-08-08 12:31 (1695 d 00:56 ago) – Posting: # 20487
Views: 7,570

Ahoy, my Capt’n,

❝ ❝ The precise model [:blahblah:]


❝ But on the other hand: Why then then include e.g. period?


[image]Cause otherwise eventual period effects would not mean out. ;-)

Given, sometimes one has to assume lacking period effects and everybody is happy with that. If an originator explores whether the drug follows linear PK, we have a paired design (SD → saturation → steady state) and compare AUC0–τ with AUC0–∞. A crossover would be a logistic nightmare.

❝ Let us for a moment disregard the actual wording. [lengthy beautiful explanation]


Exactly.

❝ […] For a parallel trial I think I want group in the model. If regulators don't like this, they can ask me to take it away. I happily do so without protesting. I am a sheep at that point. But not until then. :-D


Agree again.

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
107 visitors (0 registered, 107 guests [including 9 identified bots]).
Forum time: 12:28 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5