I love your subject line! [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2019-08-08 12:31 (1747 d 18:36 ago) – Posting: # 20487
Views: 7,837

Ahoy, my Capt’n,

❝ ❝ The precise model [:blahblah:]


❝ But on the other hand: Why then then include e.g. period?


[image]Cause otherwise eventual period effects would not mean out. ;-)

Given, sometimes one has to assume lacking period effects and everybody is happy with that. If an originator explores whether the drug follows linear PK, we have a paired design (SD → saturation → steady state) and compare AUC0–τ with AUC0–∞. A crossover would be a logistic nightmare.

❝ Let us for a moment disregard the actual wording. [lengthy beautiful explanation]


Exactly.

❝ […] For a parallel trial I think I want group in the model. If regulators don't like this, they can ask me to take it away. I happily do so without protesting. I am a sheep at that point. But not until then. :-D


Agree again.

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