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RegisterI love your subject line! [General Statistics]
posted by Helmut 
– Vienna, Austria, 2019-08-08 12:31 (1327 d 13:47 ago) – Posting: # 20487
Views: 6,866
Ahoy, my Capt’n,
![[image]](img/uploaded/image7.png)
Cause otherwise eventual period effects would not mean out. 
Given, sometimes one has to assume lacking period effects and everybody is happy with that. If an originator explores whether the drug follows linear PK, we have a paired design (SD → saturation → steady state) and compare AUC0–τ with AUC0–∞. A crossover would be a logistic nightmare.
Exactly.
Agree again.
❝ ❝ The precise model [
]
❝
❝ But on the other hand: Why then then include e.g. period?
Cause otherwise eventual period effects would not mean out. Given, sometimes one has to assume lacking period effects and everybody is happy with that. If an originator explores whether the drug follows linear PK, we have a paired design (SD → saturation → steady state) and compare AUC0–τ with AUC0–∞. A crossover would be a logistic nightmare.
❝ Let us for a moment disregard the actual wording. [lengthy beautiful explanation]
Exactly.
❝ […] For a parallel trial I think I want group in the model. If regulators don't like this, they can ask me to take it away. I happily do so without protesting. I am a sheep at that point. But not until then. 
Agree again.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Group by sequence interaction Mutasim 2019-08-07 13:16 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Group by sequence interaction, an urban myth? Helmut 2019-08-07 14:35
- pristine, genuine, holy, magnificent, inexplicable beautiful variation ElMaestro 2019-08-08 10:06
- I love your subject line!Helmut 2019-08-08 10:31
- Group effect, did you miss it? Astea 2019-12-21 14:12
- Group effect, did you miss it? PharmCat 2019-12-22 01:37
- Group effect: the endless story Helmut 2019-12-22 10:30
- Group effect: the endless river Astea 2019-12-22 21:23
- Group effect: the endless river PharmCat 2019-12-22 22:52
- replicateBE solution with interactions mittyri 2019-12-23 14:30
- replicateBE solution with interactions Astea 2019-12-23 17:26
- datasets issues mittyri 2019-12-24 10:53
- datasets Helmut 2019-12-24 11:03
- datasets Astea 2019-12-24 19:18
- lmer / lme Helmut 2019-12-25 19:12
- datasets Astea 2019-12-24 19:18
- replicateBE solution with interactions Astea 2019-12-23 17:26
- Group effect: the endless river Astea 2019-12-22 21:23
- What do you mean exactly? Beholder 2019-12-27 13:44
- What do you mean exactly? Astea 2019-12-29 21:59
- ANOVA acc. to GL Helmut 2019-12-30 12:32
- What do you mean exactly? Astea 2019-12-29 21:59
- Group effect, did you miss it? Astea 2019-12-21 14:12
- I love your subject line!Helmut 2019-08-08 10:31
- pristine, genuine, holy, magnificent, inexplicable beautiful variation ElMaestro 2019-08-08 10:06
- Group by sequence interaction, an urban myth? Helmut 2019-08-07 14:35
Ing. Helmut Schütz