Not sure whether it makes sense [Design Issues]

posted by d_labes  – Berlin, Germany, 2019-08-03 19:35  – Posting: # 20470
Views: 798

Dear Abhimanyu,

» ...
» What would be change in Proc GlM / Proc Mixed for Calculate Swr, 95% Upper bound (Scaled), and 90% CI (Unscaled):confused::confused:.

Nothing since the effects in GLM or mixed are not dependent from the used sequences, only the number of levels of the effect "sequence" or "period" changes. But this has not to be specified in the code (SAS or others). It will be taken automatically from the dataset you use.
Thus you have:
  log(PK) ~ period + sequence + subject(sequence) - for calculation of sWR
  log(PK) ~ treatment + period + sequence + subject(sequence) - for 90% CI
in R lingo.
In SAS you have to modify the model statement in Proc GLM accordingly.

Regards,

Detlew

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