Bioequivalence and Bioavailability Forum

Not sure whether it makes sense [Design Issues]

posted by abhimanyu – Banglore, 2019-08-03 13:54 (805 d 09:24 ago) – Posting: # 20469
Views: 2,287

Hi Helmut/SP,

» Maybe it is better to opt for a modified Williams’ design T1T2RR | T2RT1R | RT1RT2 | RRT2T1 which gives
» T1• RR | • RT1R | RT1R•  | RR• T1 and
» • T2RR | T2R• R | R• RT2 | RRT2• 
» At least balanced for T₁ and T₂ (once in every period).
» However, we have R twice in periods 1&2 and only once in periods 3&4.


If we consider modified Williams’ design with this sequence T1T2RR | T2RT1R | RT1RT2 | RRT2T1 Then,

What would be change in Proc GlM / Proc Mixed for Calculate Swr, 95% Upper bound (Scaled), and 90% CI (Unscaled).



Thanking you in advance!!

Complete thread:

• suggest suitable Sequence for Reference replicate and Two Different Test? SP 2019-07-29 14:31 [Design Issues] 
  • Not sure whether it makes sense Helmut 2019-07-29 17:25
    • Not sure whether it makes senseabhimanyu 2019-08-03 13:54
      • Not sure whether it makes sense d_labes 2019-08-03 19:35
        • Not sure whether it makes sense abhimanyu 2019-08-05 09:27