## Not sure whether it makes sense [Design Issues]

Hi Helmut/SP,

» Maybe it is better to opt for a modified Williams’ design T1T2RR | T2RT1R | RT1RT2 | RRT2T1 which gives
» T1• RR | • RT1R | RT1R•  | RR• T1 and
» • T2RR | T2R• R | R• RT2 | RRT2•
» At least balanced for T1 and T2 (once in every period).
» However, we have R twice in periods 1&2 and only once in periods 3&4.

If we consider modified Williams’ design with this sequence T1T2RR | T2RT1R | RT1RT2 | RRT2T1 Then,

What would be change in Proc GlM / Proc Mixed for Calculate Swr, 95% Upper bound (Scaled), and 90% CI (Unscaled).

Abhimanyu