Biorelevant Dissolution - FeSSGF with Ensure Plus [Dissolution / BCS / IVIVC]

posted by thalita_m  – Brazil, 2019-07-26 15:55 (431 d 08:48 ago) – Posting: # 20445
Views: 978

Hello everyone,

I am doing work with biorelevant dissolution media and the literature indicates the use of dietary supplements like Ensure Plus (Abott) to simulate the gastric fed medium (FeSSGF).
Has anyone around here ever done dissolution trials with this supplement? Any tips for drug recovery / extraction?

We tested using acetonitrile for extraction, the tests with the raw material showed a good recovery of the drug, but when we did the dissolution test, the drug only appeared after 30 minutes. We still do not know if it was a matter of homogenization or if the formulation did not disintegrate.

Thanks in advance.

Complete thread:

Activity
 Admin contact
21,086 posts in 4,398 threads, 1,468 registered users;
online 3 (0 registered, 3 guests [including 3 identified bots]).
Forum time: Wednesday 00:44 CEST (Europe/Vienna)

When puzzled, it never hurts to read the primary documents 
a rather simple and self-evident principle that has, nonetheless,
completely disappeared from large sectors
of the American experience.    Stephen Jay Gould

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5