Bioequivalence and Bioavailability Forum

Dear Helmut,

❝ I must confess that I don’t get what Luther Gwaza et al.^1,2 means by his “pragmatic method”:

agree, intricated explanation
In the discussion part I've found

The method based on a combination of both (SE calculation of the heteroscedastic method and degrees of freedom of the homoscedastic method), which is the simplest numerical calculation, gives results similar to those obtained with the heteroscedastic approach, showing that the contribution of the different method of calculation of the degrees of freedom is negligible.

Heteroscedatic method + simplified DFs

I also found some paper where the authors are using that approach, but I don't think their understanding of 'pragmatic' is correct