Bioequivalence and Bioavailability Forum • Spreadsheet addiction

Spreadsheet addiction [Software]

posted by Shuanghe – Spain, 2019-07-18 18:59 (549 d 18:18 ago) – Posting: # 20392
Views: 6,301

Dear all

» There is a series of papers about indirect adjusted comparisons in BE published by regulators. All done in Excel.

As far as I can tell, Excel and R give the same result. I was interested in the method so several weeks back I played with R using data from EPAR (none of the articles gives sample size of the BE study so without going to the EPAR for this additional information you can not reproduce/validate their results at all) and the difference in some comparison is 0.01% due to different rounding method used in Excel and R.

However, as Ohlbe said, there are some errors in the articles such as in the latest article (link), table 2 gives wrong data (I compared the original data from EPAR and it's clearly a mistake in article) but the result of the comparison using that data is correct, so this might just a typo. However, some comparisons were reversed, e.g., Table 3 describs generic 2 vs generic 4, and generic 3 vs generic 4, but in fact it were generic 4 vs 3 and 2, ... Apparently, someone typed the data in the wrong cell in excel so confidence interval were all reversed. :-D

» Semitransparent colors in Excel? I don’t think that’s possible. ;-)

Haha, this is where you err... :-D

Actually you can do that in Excel (not that you should). At least I can in my 2013. It's ugly, but semi-transparent it is. :cool:

—
All the best,
Shuanghe

Complete thread:

Spreadsheet failures, any recent examples? ElMaestro 2019-07-18 13:43 [Software]
- Spreadsheet failures, any recent examples? Ohlbe 2019-07-18 14:32
  - Spreadsheet addiction Helmut 2019-07-18 16:12
    - Nasty beast Ohlbe 2019-07-18 17:30
      - Nasty beast Helmut 2019-07-18 20:26
        
        Nasty beast Ohlbe 2019-07-19 11:32
        
        Nasty beast ElMaestro 2019-07-19 12:32
        
        Decidedly off topic Ohlbe 2019-07-19 13:38
        
        OT: R limbo 101 Helmut 2019-07-19 13:00
    - Spreadsheet addictionShuanghe 2019-07-18 18:59
      - Spreadsheet addiction Helmut 2019-07-18 20:04
        
        OT: Spreadsheet addiction Shuanghe 2019-07-19 12:41
        
        OT: Spreadsheet addiction Helmut 2019-07-19 14:29
        
        OT: Spreadsheet addiction nobody 2019-07-19 15:53
        
        OT: Spreadsheet addiction Helmut 2019-07-19 19:32
  - Spreadsheet etc. failures zizou 2019-07-20 00:18
    - As designed ☺ Helmut 2019-07-20 02:12
      - As designed ☺ ElMaestro 2019-07-20 09:08
        
        To round or not to round… Helmut 2019-07-20 12:53
        
        To round or not to round… ElMaestro 2019-07-20 19:59
        
        floating-point math is always more complex than you think it is mittyri 2019-07-20 22:43
- Spreadsheet failures, any recent examples? Ohlbe 2020-12-10 18:43
  - Floating point arithmetic, again Helmut 2020-12-10 19:12
    - Floating point arithmetic, again ElMaestro 2020-12-10 19:40
      - Floating point arithmetic, again Ohlbe 2020-12-10 20:18
        
        Floating point arithmetic, again ElMaestro 2020-12-10 21:38
        
        Floating point arithmetic, again Ohlbe 2020-12-10 21:46
        
        Floating point arithmetic, again ElMaestro 2020-12-10 22:05
        
        Depressed Ohlbe 2020-12-10 23:35
        
        Depressed ElMaestro 2020-12-11 07:59
    - Floating point arithmetic, again Ohlbe 2020-12-10 20:13
  - From bad to worse Ohlbe 2020-12-10 22:11
    - From bad to worse mittyri 2020-12-11 00:22
    - All is good Helmut 2020-12-11 00:36
      - Float is float PharmCat 2020-12-18 20:53
        
        Float is float! Helmut 2020-12-20 23:27
        
        rational solution in R mittyri 2020-12-21 13:49
        
        related stuff Helmut 2021-01-14 12:53