Bioequivalence and Bioavailability Forum

Spreadsheet addiction [Software]

posted by Shuanghe  – Spain, 2019-07-18 20:59 (2102 d 14:23 ago) – Posting: # 20392
Views: 24,049

Dear all

❝ There is a series of papers about indirect adjusted comparisons in BE published by regulators. All done in Excel.

As far as I can tell, Excel and R give the same result. I was interested in the method so several weeks back I played with R using data from EPAR (none of the articles gives sample size of the BE study so without going to the EPAR for this additional information you can not reproduce/validate their results at all) and the difference in some comparison is 0.01% due to different rounding method used in Excel and R.

However, as Ohlbe said, there are some errors in the articles such as in the latest article (link), table 2 gives wrong data (I compared the original data from EPAR and it's clearly a mistake in article) but the result of the comparison using that data is correct, so this might just a typo. However, some comparisons were reversed, e.g., Table 3 describs generic 2 vs generic 4, and generic 3 vs generic 4, but in fact it were generic 4 vs 3 and 2, ... Apparently, someone typed the data in the wrong cell in excel so confidence interval were all reversed.

❝ Semitransparent colors in Excel? I don’t think that’s possible.

Haha, this is where you err... Actually you can do that in Excel (not that you should). At least I can in my 2013. It's ugly, but semi-transparent it is.

Complete thread:

• Spreadsheet failures, any recent examples? ElMaestro 2019-07-18 13:43 [Software] 
  • Spreadsheet failures, any recent examples? Ohlbe 2019-07-18 14:32
    • Spreadsheet addiction Helmut 2019-07-18 16:12
      • Nasty beast Ohlbe 2019-07-18 17:30
        • Nasty beast Helmut 2019-07-18 20:26
          • Nasty beast Ohlbe 2019-07-19 11:32
            • Nasty beast ElMaestro 2019-07-19 12:32
              • Decidedly off topic Ohlbe 2019-07-19 13:38
            • OT: R limbo 101 Helmut 2019-07-19 13:00
      • Spreadsheet addictionShuanghe 2019-07-18 18:59
        • Spreadsheet addiction Helmut 2019-07-18 20:04
          • OT: Spreadsheet addiction Shuanghe 2019-07-19 12:41
            • OT: Spreadsheet addiction Helmut 2019-07-19 14:29
              • OT: Spreadsheet addiction nobody 2019-07-19 15:53
                • OT: Spreadsheet addiction Helmut 2019-07-19 19:32
    • Spreadsheet etc. failures zizou 2019-07-20 00:18
      • As designed ☺ Helmut 2019-07-20 02:12
        • As designed ☺ ElMaestro 2019-07-20 09:08
          • To round or not to round… Helmut 2019-07-20 12:53
            • To round or not to round… ElMaestro 2019-07-20 19:59
              • floating-point math is always more complex than you think it is mittyri 2019-07-20 22:43
  • Spreadsheet failures, any recent examples? Ohlbe 2020-12-10 18:43
    • Floating point arithmetic, again Helmut 2020-12-10 19:12
      • Floating point arithmetic, again ElMaestro 2020-12-10 19:40
        • Floating point arithmetic, again Ohlbe 2020-12-10 20:18
          • Floating point arithmetic, again ElMaestro 2020-12-10 21:38
            • Floating point arithmetic, again Ohlbe 2020-12-10 21:46
              • Floating point arithmetic, again ElMaestro 2020-12-10 22:05
                • Depressed Ohlbe 2020-12-10 23:35
                  • Depressed ElMaestro 2020-12-11 07:59
      • Floating point arithmetic, again Ohlbe 2020-12-10 20:13
    • From bad to worse Ohlbe 2020-12-10 22:11
      • From bad to worse mittyri 2020-12-11 00:22
      • All is good Helmut 2020-12-11 00:36
        • Float is float PharmCat 2020-12-18 20:53
          • Float is float! Helmut 2020-12-20 23:27
            • rational solution in R mittyri 2020-12-21 13:49
              • related stuff Helmut 2021-01-14 12:53
                • related stuff SDavis 2021-02-09 12:02
                  • related stuff ElMaestro 2021-02-09 19:55