Dose term in the ANOVA Model [Regulatives / Guidelines]
❝ ❝ As per the FDA guidance of Sapropterin Dihydrochloride Tablets, The total dose should be included in the ANOVA model.
❝ I believe they meant to do an ANCOVA with total dose as covariate.
❝ Your (fixed) factors would be subject, sequence, period, treatment. Note that even with the bogus
random statement in SAS when using PROC GLM the model is fit with a single random term (the 'error').
Thaks for your response.
When i keep totaldose is a factor along with normal fixed effects (seq sub(seq) per trt) the model is not execute, Please let us know what are the fixed effects is required in ANOVA model.
model Cmax AUCt AUCi= seq sub(seq) per trt totaldose / ss3;
test h= seq e=sub(seq)/htype=3 etype=3;
Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]
- Dose term in the ANOVA Model balakotu 2019-06-18 13:03 [Regulatives / Guidelines]
- Dose term in the ANOVA Model ElMaestro 2019-06-18 13:14