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RegisterBlind interim in parallel design? [Two-Stage / GS Designs]
Dear Helmut!
I am very sorry for confusing! (neither of them, but I really love your way of thinking!!) It has to mean "Blind men and an elephant", a parable about how difficult is to find the truth if you have only limited data
. That was about parallel blind studies.
![[image]](img/uploaded/image103.jpg)
As far as I understood from an article by A. Fuglsang*, heteroscedasticity should not cause problems. But for blind studies CVaverage (that is not distinguishing treatments) is not equal to CVpooled, how to deal with it? Is there a way to prove a possibility of inflation in blind parallel studies?
❝ I don’t get your subject line. Do you mean that...
I am very sorry for confusing! (neither of them, but I really love your way of thinking!!) It has to mean "Blind men and an elephant", a parable about how difficult is to find the truth if you have only limited data
. That was about parallel blind studies.❝ Simulations… Might be tricky cause we have to think about unequal group sizes and/or variances.
As far as I understood from an article by A. Fuglsang*, heteroscedasticity should not cause problems. But for blind studies CVaverage (that is not distinguishing treatments) is not equal to CVpooled, how to deal with it? Is there a way to prove a possibility of inflation in blind parallel studies?
- Fuglsang A. Sequential Bioequivalence Approaches for Parallel Design. AAPS J. 2014; 16(3):373–8. doi:10.1208/s1224801495711.
Complete thread:
- 2-stage design with interim sample size estimation d_labes 2010-10-05 15:09 [Two-Stage / GS Designs]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
- Null = bioINequivalence Helmut 2010-10-25 19:16
- 2-stage design with interim sample size estimation d_labes 2010-10-26 13:28
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind ? Ohlbe 2010-10-27 23:37
- Blind ? Jack 2010-10-28 10:24
- Blind 2Stage Astea 2019-05-30 10:37
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Which elephant? Helmut 2019-06-02 20:14
- Blind interim in parallel design?Astea 2019-06-03 01:47
- Blind men d_labes 2019-06-05 12:23
- The Blind Leading the Blind Astea 2019-06-06 00:55
- Blind men d_labes 2019-06-05 12:23
- Blind interim in parallel design?Astea 2019-06-03 01:47
- Which elephant? Helmut 2019-06-02 20:14
- Blind 2Stage and an elephant Astea 2019-05-31 14:36
- Blind 2Stage Helmut 2019-05-30 12:56
- Blind 2Stage Astea 2019-05-30 10:37
- Blind ? Jack 2010-10-28 10:24
- Blind ? Ohlbe 2010-10-27 23:37
- Blind or not, Indecisions or Decisions Jack 2010-10-27 18:14
- Blind or not, Indecisions or Decisions d_labes 2010-10-27 16:01
- 2-stage design with interim sample size estimation Jack 2010-10-26 18:26
- 2-stage design with interim sample size estimation Jack 2010-10-25 18:20
Ing. Helmut Schütz