Blind interim in parallel design? [Two-Stage / GS Designs]

posted by Astea – Russia, 2019-06-03 01:47 (1213 d 06:04 ago) – Posting: # 20312
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Dear Helmut!

» I don’t get your subject line. Do you mean that...

I am very sorry for confusing! (neither of them, but I really love your way of thinking!!) It has to mean "Blind men and an elephant", a parable about how difficult is to find the truth if you have only limited data :pirate:. That was about parallel blind studies.
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» Simulations… Might be tricky cause we have to think about unequal group sizes and/or variances.

As far as I understood from an article by A. Fuglsang*, heteroscedasticity should not cause problems. But for blind studies CVaverage (that is not distinguishing treatments) is not equal to CVpooled, how to deal with it? Is there a way to prove a possibility of inflation in blind parallel studies?



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