Blind interim in parallel design? [Two-Stage / GS Designs]

posted by Astea – Russia, 2019-06-03 03:47 (1732 d 19:31 ago) – Posting: # 20312
Views: 6,383

Dear Helmut!

❝ I don’t get your subject line. Do you mean that...


I am very sorry for confusing! (neither of them, but I really love your way of thinking!!) It has to mean "Blind men and an elephant", a parable about how difficult is to find the truth if you have only limited data :pirate:. That was about parallel blind studies.
[image]

❝ Simulations… Might be tricky cause we have to think about unequal group sizes and/or variances.


As far as I understood from an article by A. Fuglsang*, heteroscedasticity should not cause problems. But for blind studies CVaverage (that is not distinguishing treatments) is not equal to CVpooled, how to deal with it? Is there a way to prove a possibility of inflation in blind parallel studies?



Complete thread:

UA Flag
Activity
 Admin contact
22,916 posts in 4,807 threads, 1,646 registered users;
31 visitors (0 registered, 31 guests [including 5 identified bots]).
Forum time: 22:19 CET (Europe/Vienna)

Nothing shocks me. I’m a scientist.    Harrison Ford (as Indiana Jones)

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5