Blind interim in parallel design? [Two-Stage / GS Designs]

posted by Astea – Russia, 2019-06-03 01:47  – Posting: # 20312
Views: 2,279

Dear Helmut!

» I don’t get your subject line. Do you mean that...

I am very sorry for confusing! (neither of them, but I really love your way of thinking!!) It has to mean "Blind men and an elephant", a parable about how difficult is to find the truth if you have only limited data :pirate:. That was about parallel blind studies.
[image]

» Simulations… Might be tricky cause we have to think about unequal group sizes and/or variances.

As far as I understood from an article by A. Fuglsang*, heteroscedasticity should not cause problems. But for blind studies CVaverage (that is not distinguishing treatments) is not equal to CVpooled, how to deal with it? Is there a way to prove a possibility of inflation in blind parallel studies?



Complete thread:

Activity
 Admin contact
20,138 posts in 4,246 threads, 1,386 registered users;
online 20 (0 registered, 20 guests [including 10 identified bots]).
Forum time (Europe/Vienna): 07:46 CET

The fundamental cause of trouble in the world today is
that the stupid are cocksure
while the intelligent are full of doubt.    Bertrand Russell

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5