A lie is a lie is a lie ... [R for BE/BA]

posted by d_labes  – Berlin, Germany, 2019-04-25 19:59 (444 d 12:00 ago) – Posting: # 20236
Views: 4,958

Dear All,
especially the contributors to this thread.

I have a simple opinion about that mean PK profile graphs:
Whatever sophisticated group statistics underlying such mean profile you choose, whatever sophistic rules regarding missings and / or values below LLOQ, whatever sophistic graphical effects
you choose - you end with a statistical lie.
A lie
is a lie
is a lie ...

Thus my recommendation: Don't invest too many Gehirnschmalz (brain power).
Try to go without them.
And since that unfortunately doesn't function in many cases, as I know of course, choose a simple effortless solution and go with that. The Blume/Mutschler graphs shown in Helmuts post point in the correct direction.
I only had some seldom requests from some smart alecs to change the graphs. If this happens it is early enough to invest some grey matter.



Complete thread:

 Admin contact
20,822 posts in 4,356 threads, 1,448 registered users;
online 31 (1 registered, 30 guests [including 11 identified bots]).
Forum time: 07:59 CEST (Europe/Vienna)

The analysis of variance is not a mathematical theorem,
but rather a convenient method of arranging the arithmetic.    R.A. Fisher

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz