## A lie is a lie is a lie ... [R for BE/BA]

Dear All,

especially the contributors to this thread.

I have a simple opinion about that mean PK profile graphs:

Whatever sophisticated group statistics underlying such mean profile you choose, whatever sophistic rules regarding missings and / or values below LLOQ, whatever sophistic graphical effects

you choose - you end with a statistical lie.

A lie

is a lie

is a lie ...

Thus my recommendation: Don't invest too many Gehirnschmalz (brain power).

Try to go without them.

And since that unfortunately doesn't function in many cases, as I know of course, choose a simple effortless solution and go with that. The Blume/Mutschler graphs shown in Helmuts post point in the correct direction.

I only had some seldom requests from some smart alecs to change the graphs. If this happens it is early enough to invest some grey matter.

especially the contributors to this thread.

I have a simple opinion about that mean PK profile graphs:

Whatever sophisticated group statistics underlying such mean profile you choose, whatever sophistic rules regarding missings and / or values below LLOQ, whatever sophistic graphical effects

you choose - you end with a statistical lie.

A lie

is a lie

is a lie ...

Thus my recommendation: Don't invest too many Gehirnschmalz (brain power).

Try to go without them.

And since that unfortunately doesn't function in many cases, as I know of course, choose a simple effortless solution and go with that. The Blume/Mutschler graphs shown in Helmuts post point in the correct direction.

I only had some seldom requests from some smart alecs to change the graphs. If this happens it is early enough to invest some grey matter.

—

Regards,

Detlew

Regards,

Detlew

### Complete thread:

- Graphing Mean PK profile roman_max 2019-04-23 16:01 [R for BE/BA]
- Graphing Mean PK profile Shuanghe 2019-04-23 18:31
- Graphing Mean PK profile roman_max 2019-04-24 12:29

- Graphing Mean PK profile Helmut 2019-04-23 22:23
- Graphing Mean PK profile nobody 2019-04-24 11:23
- Graphing Mean PK profile Helmut 2019-04-24 11:49
- Graphing Mean PK profile nobody 2019-04-24 11:53
- Graphing Mean PK profile Helmut 2019-04-24 12:32
- Graphing Mean PK profile nobody 2019-04-24 12:49

- Graphing Mean PK profile Helmut 2019-04-24 12:32

- Graphing Mean PK profile nobody 2019-04-24 11:53

- Graphing Mean PK profile Helmut 2019-04-24 11:49
- Graphing Mean PK profile roman_max 2019-04-24 12:36
- Graphing Mean PK profile Helmut 2019-04-24 13:50
- Graphing Mean PK profile nobody 2019-04-24 14:15
- Graphing Mean PK profile Helmut 2019-04-24 14:41
- Pasta Ohlbe 2019-04-25 12:47
- Pasta nobody 2019-04-25 14:36
- Spaghetti Viennese Helmut 2019-04-25 14:39
- Spaghetti Viennese nobody 2019-04-25 15:08
- OT: Blume/Mutschler Helmut 2019-04-25 15:32
- OT: Blume/Mutschler nobody 2019-04-25 15:43

- OT: Blume/Mutschler Helmut 2019-04-25 15:32

- Spaghetti Viennese nobody 2019-04-25 15:08

- Pasta Ohlbe 2019-04-25 12:47

- Graphing Mean PK profile Helmut 2019-04-24 14:41

- Graphing Mean PK profile nobody 2019-04-24 14:15

- Graphing Mean PK profile Helmut 2019-04-24 13:50
- A lie is a lie is a lie ...d_labes 2019-04-25 19:59

- Graphing Mean PK profile nobody 2019-04-24 11:23

- Graphing Mean PK profile Shuanghe 2019-04-23 18:31