A lie is a lie is a lie ... [R for BE/BA]

posted by d_labes  – Berlin, Germany, 2019-04-25 19:59  – Posting: # 20236
Views: 2,208

Dear All,
especially the contributors to this thread.

I have a simple opinion about that mean PK profile graphs:
Whatever sophisticated group statistics underlying such mean profile you choose, whatever sophistic rules regarding missings and / or values below LLOQ, whatever sophistic graphical effects
you choose - you end with a statistical lie.
A lie
is a lie
is a lie ...

Thus my recommendation: Don't invest too many Gehirnschmalz (brain power).
Try to go without them.
And since that unfortunately doesn't function in many cases, as I know of course, choose a simple effortless solution and go with that. The Blume/Mutschler graphs shown in Helmuts post point in the correct direction.
I only had some seldom requests from some smart alecs to change the graphs. If this happens it is early enough to invest some grey matter.

Regards,

Detlew

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,889 posts in 4,215 threads, 1,364 registered users;
online 7 (0 registered, 7 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 09:15 CEST

I have no opinion about ‘incurred samples’ –
an expression which has no easily understandable
meaning for me in the English language.    Nick Holford

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5