Spaghetti Viennese [R for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2019-04-25 14:39  – Posting: # 20231
Views: 2,850

Dear Ohlbe,

» » I’m pissed when I get a report without spaghetti plots.
»
» And you complain that overlaying two plots of means is too crowded ;-)

Nope. Overlaying two plots ±SD. I’m fine with one plot of both T and R plus two showing the treatments separately (geom. mean ±SD).

» I find spaghetti plots rather difficult to read with more than 30 subjects, or even less depending on what they look like...

You get used to it. ;-)
Our brains are great in pattern-recognition. Two examples (amoxicillin 1 g tablets, different tests but same reference in both studies) of Blume/Mutschler*

Study  metric    90% CI 
────────────────────────
  1     AUC    92 – 111%
        Cmax   87 – 109%
  2     AUC    82 –  99%
        Cmax   75 –  99%

Both studies passed (limits for AUC 80–125% and for Cmax 70–143%).
@ Mittyri: Good ol’ days! :waving:

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I would say:This loose leaf edition (~2,000 pages in 4 volumes, 1989–1996) was prepared for the ABDA („Bundesvereinigung Deutscher Apotherverbände” – Federal Union of German Associations of Pharmacists) to provide pharmacists a means to decide which generic to chose. Already in 1992 ⅓ of all German pharmacists completed a training on BE provided by the ZL (“Zentrallaboratorium Deutscher Apotheker” – Central Laboratory of German Pharmacists). Compare that to the FDA’s Orange Book…



Cheers,
Helmut Schütz
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