## Graphing Mean PK profile [R for BE/BA]

Dear roman_max,

» Can anyone share idea (R-code?) how to do it? How a data-set can be organized for this graph?

Assuming that your data file of individual concentration dat_ind contain at least the following variables: subj, treat, time, conc, you can get mean profile data with
library(dplyr) dat_mean <- dat_ind %>%   group_by(treat, time) %>%   summarise(conc = mean(conc))

Obviously, time  here should be the planned nominal time, not the actual sampling time. With ggplot you can have more or less what you asked for:

library(ggplot2) p1 <- ggplot(data = dat_ind, aes(x = time, y = conc, color = treat)) +   geom_point(aes(group = interaction(treat, time)), alpha = 0.5, shape = 1,              position = position_jitter(width = 0.1, height = 0)) +   geom_boxplot(aes(fill = treat, group = interaction(treat, time)), alpha = 0.3) +   geom_line(data = dat_mean, size = 1.3)

The main idea is the group = interaction(treat, time). Feel free to modify the rest to better suit your needs (size/shape of the points etc). position_jitter() helps to avoid point overlapping (you have to specify height = 0 otherwise the data points will not reflect the true concentration value since some randomness will be introduced along y-axis by default) and the last line will add mean profiles with slightly bold lines.

All the best,
Shuanghe