Bioequivalence and Bioavailability Forum • Metrics for absorption

Metrics for absorption [NCA / SHAM]

posted by Helmut – Vienna, Austria, 2019-04-16 19:01 (1830 d 04:58 ago) – Posting: # 20176
Views: 7,423

Hi nobody,

method of residuals, feathering, Wagner-Nelson? Smells of modeling which is not acceptable in BE. BTW, lag-times are the killer. Good luck!^1,2

Nerella NG, Block NH, Noonan PK. The Impact of Lag Time on the Estimation of Pharmacokinetic Parameters. I. One Compartment Model. Pharm Res. 1993;10(7):1031–6.
Csizmadia F, Endrényi L. Model-Independent Estimation of Lag Times with First-Order Absorption and Disposition. J Pharm Sci. 1998;87(5):608–12. doi:10.1021/js9703333

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Complete thread:

Metrics for absorption Helmut 2019-04-15 12:08 [NCA / SHAM]
- Metrics for absorption nobody 2019-04-15 12:15
  - Metrics for absorption ElMaestro 2019-04-15 12:23
    - Metrics for absorption nobody 2019-04-15 12:39
  - Metrics for absorption Helmut 2019-04-15 13:02
    - Metrics for absorption nobody 2019-04-15 13:48
      - Metrics for absorption Helmut 2019-04-15 19:31
        
        Metrics for absorption nobody 2019-04-16 09:34
        
        Metrics for absorption nobody 2019-04-16 15:15
        
        Metrics for absorptionHelmut 2019-04-16 17:01
        
        Metrics for absorption nobody 2019-04-17 11:15
        
        Simulation framework mittyri 2019-04-17 01:21
        
        Simulation framework Helmut 2019-04-17 13:31
        
        Conclusion mittyri 2019-04-17 15:42
        
        Conclusion & beyond Helmut 2019-04-17 17:05