Metrics for absorption [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2019-04-16 17:01  – Posting: # 20176
Views: 306

Hi nobody,

method of residuals, feathering, Wagner-Nelson? Smells of modeling which is not acceptable in BE. BTW, lag-times are the killer. Good luck!1,2


  1. Nerella NG, Block NH, Noonan PK. The Impact of Lag Time on the Estimation of Pharmacokinetic Parameters. I. One Compartment Model. Pharm Res. 1993;10(7):1031–6.
  2. Csizmadia F, Endrényi L. Model-Independent Estimation of Lag Times with First-Order Absorption and Disposition. J Pharm Sci. 1998;87(5):608–12. doi:10.1021/js9703333

Cheers,
Helmut Schütz
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