Metrics for absorption [NCA / SHAM]

posted by nobody – 2019-04-15 10:15 (556 d 10:15 ago) – Posting: # 20164
Views: 4,383

Hi

first thought

"Cmax is ...is nonspecific to it (reflects also the extent of absorption as well as the rates of disposition processes),..."

Hmm, how is AUCp not reflecting disposition processes?

"...lacks kinetic sensitivity even following a single administration."

How much sensitivity is needed in the first place? Or are we creating problems by "overly sensitive" methods with no relevance in clinical practice?

Kindest regards, nobody

Complete thread:

Activity
 Admin contact
21,177 posts in 4,414 threads, 1,475 registered users;
online 7 (0 registered, 7 guests [including 3 identified bots]).
Forum time: Thursday 20:31 UTC (Europe/Vienna)

It is not so much that I have confidence in scientists being right,
but that I have so much in nonscientists being wrong.    Isaac Asimov

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5