Metrics for absorption [NCA / SHAM]
Hi
first thought
"Cmax is ...is nonspecific to it (reflects also the extent of absorption as well as the rates of disposition processes),..."
Hmm, how is AUCp not reflecting disposition processes?
"...lacks kinetic sensitivity even following a single administration."
How much sensitivity is needed in the first place? Or are we creating problems by "overly sensitive" methods with no relevance in clinical practice?
first thought
"Cmax is ...is nonspecific to it (reflects also the extent of absorption as well as the rates of disposition processes),..."
Hmm, how is AUCp not reflecting disposition processes?
"...lacks kinetic sensitivity even following a single administration."
How much sensitivity is needed in the first place? Or are we creating problems by "overly sensitive" methods with no relevance in clinical practice?
—
Kindest regards, nobody
Kindest regards, nobody
Complete thread:
- Metrics for absorption Helmut 2019-04-15 12:08 [NCA / SHAM]
- Metrics for absorptionnobody 2019-04-15 12:15
- Metrics for absorption ElMaestro 2019-04-15 12:23
- Metrics for absorption nobody 2019-04-15 12:39
- Metrics for absorption Helmut 2019-04-15 13:02
- Metrics for absorption nobody 2019-04-15 13:48
- Metrics for absorption Helmut 2019-04-15 19:31
- Metrics for absorption nobody 2019-04-16 09:34
- Metrics for absorption nobody 2019-04-16 15:15
- Metrics for absorption Helmut 2019-04-16 17:01
- Metrics for absorption nobody 2019-04-17 11:15
- Metrics for absorption Helmut 2019-04-16 17:01
- Metrics for absorption nobody 2019-04-16 15:15
- Simulation framework mittyri 2019-04-17 01:21
- Simulation framework Helmut 2019-04-17 13:31
- Conclusion mittyri 2019-04-17 15:42
- Conclusion & beyond Helmut 2019-04-17 17:05
- Conclusion mittyri 2019-04-17 15:42
- Simulation framework Helmut 2019-04-17 13:31
- Metrics for absorption nobody 2019-04-16 09:34
- Metrics for absorption Helmut 2019-04-15 19:31
- Metrics for absorption nobody 2019-04-15 13:48
- Metrics for absorption ElMaestro 2019-04-15 12:23
- Metrics for absorptionnobody 2019-04-15 12:15