Bioequivalence and Bioavailability Forum • Pooled vs IBD T-R in SAS from non-SASian

Pooled vs IBD T-R in SAS from non-SASian [Design Issues]

posted by mittyri – Russia, 2019-03-24 00:13 (2245 d 05:11 ago) – Posting: # 20073
Views: 28,620

Dear Helmut,

❝ A request to the SASians of the forum: Please run Proc MIXED with DDFM=SATTERTHWAITE of the pooled data and both DDFM-options on the data where S is excluded.

Here's my (naive) attempt

<...>

ODS output estimates = _pooled;



proc mixed data=ex631 method=reml ITDETAILS maxiter=200;

class sequence subject period formula carry;

model ln_auc= sequence period formula/ddfm=SATTERTHWAITE outp=out;

random subject(sequence);

estimate 't T-R' formula -1 0 1/cl alpha=0.10;;

run;



Data _pooled;

set _pooled;

pe=round(100*exp(estimate), 0.00001);

lowerCL = lower;

upperCL = upper;

lower=round(100*exp(lowerCL), 0.00001);

upper=round(100*exp(upperCL), 0.00001);

run;



Data noS;

set ex631;

if formula = 'R' | formula = 'T';

run;



ODS output estimates = _TRonly;



proc mixed data=noS method=reml ITDETAILS maxiter=200;

class sequence subject period formula carry;

model ln_auc= sequence period formula/ddfm=SATTERTHWAITE outp=out;

random subject(sequence);

estimate 'T-R' formula -1 1/cl alpha=0.10;;

run;



Data _TRonly;

set _TRonly;

pe=round(100*exp(estimate), 0.00001);

lowerCL = lower;

upperCL = upper;

lower=round(100*exp(lowerCL), 0.00001);

upper=round(100*exp(upperCL), 0.00001);

run;

Results:


Option Label  Estimate StdErr DF tValue Probt Alpha Lower Upper    pe        lowerCL    upperCL

Pooled "t T-R" 0.1497 0.03848 115 3.89 0.0002 0.1  108.97 123.81 116.153  0.0859308889 0.2135523619

IBD     T-R    0.1488 0.03793 56.8 3.92 0.0002 0.1 108.92 123.65 116.047  0.0854035502 0.2122465728

—
Kind regards,
Mittyri

Complete thread:

Three-way crossover BABE Studies acfalcao 2007-09-16 22:34 [Design Issues]
- Three-way crossover example data set Helmut 2007-09-17 20:47
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