old, obvious? [Bioanalytics]

posted by ElMaestro  – Denmark, 2019-03-19 08:26 (761 d 16:37 ago) – Posting: # 20049
Views: 3,331

Hi Hötzi,

» Congratulations for an obvious solution (aka, re-inventing the wheel). ;-) See what Ohlbe wrote here and there.

Is the proposal really old and is it really obvious?

I see there was in the past a proposal or two about 1/(Conc^z) where z is not an integer, but I am not sure if there was ever anyone who:
  1. Defined an objective function which seeks to minimize a relevant measure of departure from predictability (that same predictability which maps into the criteria of guidelines).
  2. Showed the existence of a minimum of that function.

Novelty here is not the existence of a funky value of z, but the way of finding it, the nature of it.

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,419 posts in 4,475 threads, 1,509 registered users;
online 10 (0 registered, 10 guests [including 5 identified bots]).
Forum time: Monday 02:03 CEST (Europe/Vienna)

There is one certainty in drug development
and statistics that one can depend on:
the data are always late.    Scott Patterson and Byron Jones

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5