one study, one method [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-03-13 18:23  – Posting: # 20026
Views: 501

Salam Osama,

» […] The use of two methods or technologies within a
» comparative BA/BE study is strongly discouraged:. ( i.e not applicable at all also with cross-validation).:confused::confused:
» Why ??

Honestly, I would not feel comfortable with such an approach as well. Even if two methods are fully validated and cross-validated against each other. Though, at least in a crossover it should be OK.
I faced very few examples that a validated method (you know, only spiked samples…) turned out to perform “not so good” on real samples. In these cases we developed another method and re-analysed all samples with the new method. I cannot imagine a situation when someone would change a suitable method within a study just for fun.

Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. ☼
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On two occasions I have been asked,—“Pray, Mr. Babbage,
if you put into the machine wrong figures,…
will the right answers come out?”

I am not able rightly to apprehend the kind of confusion of ideas
that could provoke such a question.    Charles Babbage

BEBAC Ing. Helmut Schütz