one study, one method [Regulatives / Guidelines]

posted by Helmut Homepage – Vienna, Austria, 2019-03-13 19:23 (1918 d 17:00 ago) – Posting: # 20026
Views: 4,859

Salam Osama,

❝ […] The use of two methods or technologies within a

comparative BA/BE study is strongly discouraged:. ( i.e not applicable at all also with cross-validation).:confused::confused:

❝ Why ??


Honestly, I would not feel comfortable with such an approach as well. Even if two methods are fully validated and cross-validated against each other. Though, at least in a crossover it should be OK.
I faced very few examples that a validated method (you know, only spiked samples…) turned out to perform “not so good” on real samples. In these cases we developed another method and re-analysed all samples with the new method. I cannot imagine a situation when someone would change a suitable method within a study just for fun.

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