Bioequivalence and Bioavailability Forum

Dear Helmut, dear All!

Since this is already version 4.3.something I wouldn't expect Helmut's results in testing this piece of software.

At least not since our release of the reference datasets and the Kinetica fiasco.*
It should be more mature IMHO.

And at least not since the company behind this ThothPro™ was already founded in 2014, 5 years ago! Whatever this is, ThothPro™. Whatever this means: "Our proprietary SeshatPro™ platform serves as a template for constructing software using a novel, more logical way or writing the code. Resulting solutions are orders of magnitude faster than the existing ones, and are easy to use due to their intuitive interfaces taking full advantage of consistently using menus expandable with the right click of a mouse. Our first software based on principles of the SeshatPro™ is TP4.3 for pharmacometric calculations and modeling."
Poland has not perished yet?
Proprietary software beating them all? Validated?

I myself doesn't understand at all. Any body out there to enlighten me?

Does it mean they have discovered the right mouse button? Or have they found the "philosopher's stone" to program all the tasks associated with BE studies, beginning from NCA up to all the necessary statistics for deciding bioequivalence?

Does anybody know someone which had used this software for real BE studies in the past up to now? If yes with which regulatory outcome?

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• Schütz H, Labes D, Fuglsang A. Reference Datasets for 2-Treatment, 2-Sequence, 2-Period Bioequivalence Studies. AAPS J. 2014;16(6):1292–7. doi:10.1208/s12248-014-9661-0. PMID 25212768.  PMC Free Full text.