calibration curve range [Bioanalytics]

posted by wienui  – Germany, Oman, 2019-02-20 18:32 (979 d 15:45 ago) – Posting: # 19945
Views: 3,091

(edited by wienui on 2019-02-21 05:30)

» Salam Osama,
»
» » In a BE study, the average Cmax of subjects samples was found out of the ULOQ of the calibration curve.
»
» You’ve gotta be kidding! :-D

Salam Helmut,

No, my friend, I hoped I were kidding but unfortunately this is the reality. Moreover, it was given as a justification that samples were reanalyzed after dilution with blank human plasma to bring the analyte concentration into the validated calibration curve range which then multiplied by the dilution factor and reported in the final table of concentrations and that only 5% of subjects'samples have concentrations above ULOQ ( although we speak about the average Cmax!!!)

very nice!!!!
regards,
Osama

Cheers,
Osama

Complete thread:

Activity
 Admin contact
21,758 posts in 4,550 threads, 1,545 registered users;
online 7 (1 registered, 6 guests [including 4 identified bots]).
Forum time: Wednesday 11:17 CEST (Europe/Vienna)

There ain’t no rules around here!
We’re trying to accomplish something!    Thomas Alva Edison

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5