Bioequivalence and Bioavailability Forum

type known.designs() in PowerTOST [Study As­sess­ment]

posted by Helmut  – Vienna, Austria, 2019-02-20 17:14 (2219 d 06:10 ago) – Posting: # 19941
Views: 11,937

Hi Rosy,

❝ But in this case: https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127009903901108?sid=nlm%3Apubmed

❝

❝ The study had an open-label, single-dose, three-way crossover design. Subjects were randomly assigned to receive one of three treatments per period

Was it a Latin Square (ABC|BCA|CAB) or a Williams’s design (ABC|ACB|BAC|BCA|CAB|CBA)? Not mentioned anywhere in the paper. But this part is strange:

Seventeen healthy [] were enrolled.

Enrolled, how comes? It is OK to have dropouts but to start a study with incomplete sequences is bizarre. The sample size has to be a multiple of the number of sequences.

❝ A vs B ----> IC (84.9-106)

❝ A vs C ----> IC (169-211)

❝ B vs C ----> IC (178-222)

❝

❝ 100*CVfromCI(lower=0.849, upper=1.06, n=17, design='2x2x3', alpha=0.05)

❝ it's that correct???

No, it isn’t. "2x2x3" is for the two-treatment two-sequence three-period full replicate design (TRT|RTR).
For the Latin Square use "3x3" and for the Williams’ design "3x6x3". BTW, in all functions of PowerTOST the default is alpha=0.05. As long as you deal with the 100(1–2×0.05) = 90% confidence interval you can simply leave it out.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 12:31 [Study As­sess­ment] 
  • CV values in BE studies: intra, or inter, or total? jag009 2018-01-20 19:18
    • CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 21:10
      • CV values in BE studies: intra, or inter, or total? jag009 2018-01-21 03:17
        • CV values in BE studies: intra, or inter, or total? Elena777 2018-01-21 08:21
  • CV values in BE studies: intra, or inter, or total? Helmut 2018-01-21 17:33
  • CV values in BE studies: intra, or inter, or total? ElMaestro 2018-01-21 18:17
    • CV values in BE studies: intra, or inter, or total? Elena777 2018-01-27 09:57
      • CV values in BE studies: intra, or inter, or total? Louis52 2018-02-07 20:22
        • CV values in BE studies: intra, or inter, or total? Helmut 2018-02-07 20:31
          • CV values in BE studies: intra, or inter, or total? Rosy 2019-02-19 18:33
            • PowerTOST: CVfromCI Helmut 2019-02-20 13:00
              • PowerTOST: CVfromCI -> CI.BE d_labes 2019-02-20 14:12
                • Oops! Helmut 2019-02-20 15:32
                  • Oops! df? d_labes 2019-02-20 19:45
                    • Oops! df? Helmut 2019-02-20 20:43
                      • Oops! df! d_labes 2019-02-21 10:54
                      • Oops! df? zizou 2019-02-21 11:33
                        • Oops! df? nobody 2019-02-21 12:42
                        • All the answers are here d_labes 2019-02-21 14:49
              • PowerTOST: CVfromCI Rosy 2019-02-20 15:25
                • type known.designs() in PowerTOSTHelmut 2019-02-20 16:14
                  • type known.designs() in PowerTOST Rosy 2019-02-20 17:14