Oops! [Study Assessment]
❝ IMHO this suggestion is an orouboros.
Oh dear, it is!
❝ Calculating the CV from the CI and using this CV to calculate the CI will give you always the CI used in the starting step. Regardless of the design used in both steps.
❝ As you has demonstrated with your calculations .
Shit. Not that easy. Second try with a simple example. My data:
sub per seq trt PK
1 1 ACBD A 1.0793
1 2 ACBD C 1.1324
1 3 ACBD B 0.9422
1 4 ACBD D 0.7828
2 1 BADC B 1.0005
2 2 BADC A 1.1138
2 3 BADC D 0.7245
2 4 BADC C 0.9690
3 1 CDAB C 0.8392
3 2 CDAB D 0.8110
3 3 CDAB A 1.1333
3 4 CDAB B 1.0058
4 1 DBCA D 0.7478
4 2 DBCA B 0.8006
4 3 DBCA C 1.1432
4 4 DBCA A 0.9911
5 1 ACBD A 1.4136
5 2 ACBD C 0.8082
5 3 ACBD B 1.3025
5 4 ACBD D 1.4506
6 1 BADC B 1.0167
6 2 BADC A 0.9470
6 3 BADC D 1.5021
6 4 BADC C 1.2398
7 1 CDAB C 1.3904
7 2 CDAB D 1.2809
7 3 CDAB A 1.3593
7 4 CDAB B 1.3605
8 1 DBCA D 1.0852
8 2 DBCA B 0.9390
8 3 DBCA C 1.2467
8 4 DBCA A 1.2721
9 1 ACBD A 1.3878
9 2 ACBD C 1.2703
9 3 ACBD B 1.5533
9 4 ACBD D 1.3324
10 1 BADC B 1.1792
10 2 BADC A 0.9035
10 3 BADC D 1.1517
10 4 BADC C 1.1225
11 1 CDAB C 1.1025
11 2 CDAB D 1.0596
11 3 CDAB A 1.5024
11 4 CDAB B 0.8432
12 1 DBCA D 1.1236
12 2 DBCA B 1.3696
12 3 DBCA C 0.6106
12 4 DBCA A 0.6973
Test Method PE 90% CI CVintra
B pooled ANOVA 96.62 83.41 111.91 21.45
Two-at-a-Time 96.62 80.90 115.39 23.72
C pooled ANOVA 93.16 80.43 107.91 21.45
Two-at-a-Time 93.16 82.48 105.23 16.15
D pooled ANOVA 93.79 80.97 108.64 21.45
Two-at-a-Time 93.79 79.44 110.74 22.47
Say the CIs of the three comparisons are published but not the method. Two cases:
- The analysis was performed by the pooled ANOVA.
If we plug in the CIs of B/A, C/A, and D/A we get in all comparisons 21.45% for the pooled ANOVA and 20.06% for the Two-at-a-Time Principle (TaaTP).
- The analysis was performed by the TaaTP.
We get different results, namely for
B/A: 26.05% and 24.35%
C/A: 17.71% and 16.57%
D/A: 24.32% and 22.73%
What puzzles me is that in the latter case the calculated CVs don’t match the models’ (24.35↔23.72, 16.57↔16.15, 22.73↔22.47). Knapp vorbei ist auch daneben. Degrees of freedom?
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Helmut Schütz
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Science Quotes
Complete thread:
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 12:31 [Study Assessment]
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-20 19:18
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 21:10
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-21 03:17
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-21 08:21
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-21 03:17
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 21:10
- CV values in BE studies: intra, or inter, or total? Helmut 2018-01-21 17:33
- CV values in BE studies: intra, or inter, or total? ElMaestro 2018-01-21 18:17
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-27 09:57
- CV values in BE studies: intra, or inter, or total? Louis52 2018-02-07 20:22
- CV values in BE studies: intra, or inter, or total? Helmut 2018-02-07 20:31
- CV values in BE studies: intra, or inter, or total? Rosy 2019-02-19 18:33
- PowerTOST: CVfromCI Helmut 2019-02-20 13:00
- PowerTOST: CVfromCI -> CI.BE d_labes 2019-02-20 14:12
- PowerTOST: CVfromCI Rosy 2019-02-20 15:25
- type known.designs() in PowerTOST Helmut 2019-02-20 16:14
- type known.designs() in PowerTOST Rosy 2019-02-20 17:14
- type known.designs() in PowerTOST Helmut 2019-02-20 16:14
- PowerTOST: CVfromCI Helmut 2019-02-20 13:00
- CV values in BE studies: intra, or inter, or total? Rosy 2019-02-19 18:33
- CV values in BE studies: intra, or inter, or total? Helmut 2018-02-07 20:31
- CV values in BE studies: intra, or inter, or total? Louis52 2018-02-07 20:22
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-27 09:57
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-20 19:18