PowerTOST: CVfromCI [Study As­sess­ment]

posted by Rosy – Mexico, 2019-02-20 15:25 (509 d 19:01 ago) – Posting: # 19939
Views: 5,447

(edited by Rosy on 2019-02-20 15:37)

»              Not interested in other members’ opinions?

I'm sorry if I looked rude, I was just trying to follow the thread of the publication ... of course, I'm interested in any opinion. My deepest apologies to everyone.

» Parallel‽

I had a miscomprehension of the statistical analysis, i read again and they used an ANOVA included the following factors: sequence (SEQ), subject nested within sequence (SUBJECT [SEQ]), period (PHASE), and treatment (TREAT). I though that they maked a paired comparation, one at time.

But in this case: https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127009903901108?sid=nlm%3Apubmed

The study had an open-label, single-dose, three-way crossover design. Subjects were randomly assigned to receive one of three treatments per period

Design: 3x2 N= 17

A vs B ----> IC (84.9-106)
A vs C ----> IC (169-211)
B vs C ----> IC (178-222)

How to calculate %CV Intra-individual???

100*CVfromCI(lower=0.849, upper=1.06, n=17, design='2x2x3', alpha=0.05)

it's that correct???

Complete thread:

Activity
 Admin contact
20,834 posts in 4,358 threads, 1,449 registered users;
online 27 (1 registered, 26 guests [including 14 identified bots]).
Forum time: 11:27 CEST (Europe/Vienna)

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5