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I'm sorry if I looked rude, I was just trying to follow the thread of the publication ... of course, I'm interested in any opinion. My deepest apologies to everyone.
» Parallel‽
I had a miscomprehension of the statistical analysis, i read again and they used an ANOVA included the following factors: sequence (SEQ), subject nested within sequence (SUBJECT [SEQ]), period (PHASE), and treatment (TREAT). I though that they maked a paired comparation, one at time.
But in this case: https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127009903901108?sid=nlm%3Apubmed
The study had an open-label, single-dose, three-way crossover design. Subjects were randomly assigned to receive one of three treatments per period
Design: 3x2 N= 17
A vs B ----> IC (84.9-106)
A vs C ----> IC (169-211)
B vs C ----> IC (178-222)
How to calculate %CV Intra-individual???
100*CVfromCI(lower=0.849, upper=1.06, n=17, design='2x2x3', alpha=0.05)
it's that correct???
I'm sorry if I looked rude, I was just trying to follow the thread of the publication ... of course, I'm interested in any opinion. My deepest apologies to everyone.
» Parallel‽
I had a miscomprehension of the statistical analysis, i read again and they used an ANOVA included the following factors: sequence (SEQ), subject nested within sequence (SUBJECT [SEQ]), period (PHASE), and treatment (TREAT). I though that they maked a paired comparation, one at time.
But in this case: https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127009903901108?sid=nlm%3Apubmed
The study had an open-label, single-dose, three-way crossover design. Subjects were randomly assigned to receive one of three treatments per period
Design: 3x2 N= 17
A vs B ----> IC (84.9-106)
A vs C ----> IC (169-211)
B vs C ----> IC (178-222)
How to calculate %CV Intra-individual???
100*CVfromCI(lower=0.849, upper=1.06, n=17, design='2x2x3', alpha=0.05)
it's that correct???
Complete thread:
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 12:31 [Study Assessment]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-20 19:18
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 21:10
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-21 03:17
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-21 08:21
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-21 03:17
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 21:10
- CV values in BE studies: intra, or inter, or total? Helmut 2018-01-21 17:33
- CV values in BE studies: intra, or inter, or total? ElMaestro 2018-01-21 18:17
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-27 09:57
- CV values in BE studies: intra, or inter, or total? Louis52 2018-02-07 20:22
- CV values in BE studies: intra, or inter, or total? Helmut 2018-02-07 20:31
- CV values in BE studies: intra, or inter, or total? Rosy 2019-02-19 18:33
- PowerTOST: CVfromCI Helmut 2019-02-20 13:00
- PowerTOST: CVfromCI -> CI.BE d_labes 2019-02-20 14:12
- PowerTOST: CVfromCIRosy 2019-02-20 15:25
- type known.designs() in PowerTOST Helmut 2019-02-20 16:14
- type known.designs() in PowerTOST Rosy 2019-02-20 17:14
- type known.designs() in PowerTOST Helmut 2019-02-20 16:14
- PowerTOST: CVfromCI Helmut 2019-02-20 13:00
- CV values in BE studies: intra, or inter, or total? Rosy 2019-02-19 18:33
- CV values in BE studies: intra, or inter, or total? Helmut 2018-02-07 20:31
- CV values in BE studies: intra, or inter, or total? Louis52 2018-02-07 20:22
- CV values in BE studies: intra, or inter, or total? Elena777 2018-01-27 09:57
- CV values in BE studies: intra, or inter, or total? jag009 2018-01-20 19:18
Ing. Helmut Schütz