PowerTOST: CVfromCI -> CI.BE [Study As­sess­ment]

posted by d_labes  – Berlin, Germany, 2019-02-20 14:12  – Posting: # 19938
Views: 3,113

Dear Helmut,

» ...
» How to discover which method was used?
» Work backwards, i.e., see with which CV you can reproduce the reported results for each comparison.
» res.1 <- CI.BE(pe=pe, CV=CV.1, n=n, design=des)
» res.2 <- CI.BE(pe=pe, CV=CV.2, n=n, design=eval)
» cat(paste0("\nBack-calculated 90% CI by",
»     "\n  Pooled ANOVA           : ",
»     sprintf("%.2f%%%s", 100*res.1[["lower"]], "\u2013"),
»     sprintf("%.2f%%", 100*res.1[["upper"]]),
»     "\n  Two-at-a-Time Principle: ",
»     sprintf("%.2f%%%s", 100*res.2[["lower"]], "\u2013"),
»     sprintf("%.2f%%", 100*res.2[["upper"]]), "\n"))
»
» Back-calculated 90% CI by
»   Pooled ANOVA           : 85.00%–106.18%
»   Two-at-a-Time Principle: 85.00%–106.18%


IMHO this suggestion is an orouboros.
Calculating the CV from the CI and using this CV to calculate the CI will give you always the CI used in the starting step. Regardless of the design used in both steps.
As you has demonstrated with your calculations :cool:.

Regards,

Detlew

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,871 posts in 4,212 threads, 1,364 registered users;
online 14 (0 registered, 14 guests [including 5 identified bots]).
Forum time (Europe/Vienna): 13:29 CEST

A drug is not bad. A drug is a chemical compound.
The problem comes in when people who take drugs treat them
like a license to behave like an asshole.    Frank Zappa

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5