CV values in BE studies: intra, or inter, or total? [Study As­sess­ment]

posted by Rosy – Mexico, 2019-02-19 18:33 (1193 d 00:41 ago) – Posting: # 19934
Views: 9,218

Dear Helmut,

Accordig to the first post, i have a doubt. If i found an article of a BABE study in which 3 formulation where evaluated against to reference (A) in a 4 way crossover study, but in a bioequivalence table appears for example A vs B treatment and its respective Geometric Mean Ratio (IC 90%). If i wanna calculate CV% intrasubject ussing POWER.TOST which desing i have to pick up (4x4 or parallel)? Of course 4x4 is the real design but the comparative A vs B is technically a parallel study.

Kind Regards

Complete thread:

UA Flag
Activity
 Admin contact
22,110 posts in 4,630 threads, 1,567 registered users;
online 4 (0 registered, 4 guests [including 2 identified bots]).
Forum time: Friday 20:14 CEST (Europe/Vienna)

We absolutely must leave room for doubt
or there is no progress and no learning.
There is no learning without having to pose a question.
And a question requires doubt.
People search for certainty.
But there is no certainty.    Richard Feynman

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5