ANOVA fixed and random effects [General Sta­tis­tics]

posted by Babe_Ruth – USA, 2019-02-08 18:32  – Posting: # 19889
Views: 3,077

What's the appropriate ANOVA model for a two treatment, two period, fixed sequence study?

It's a food effect study where the subject takes the study drug under fasted conditions, 14-day washout, then takes study drug under fed conditions. The proposed is ANOVA model is to analyze log-transformed Cmax and AUClast with terms for treatment condition (Fasted and Fed) as a fixed effect and subject as a random effect.

Is this appropriate, and why or why not?

Compared to the standard 2x2 crossover study, what are the limitations of the above study design in terms of assessing inter- and intra-subject variability?

Complete thread:

Activity
 Admin contact
20,635 posts in 4,324 threads, 1,434 registered users;
online 17 (1 registered, 16 guests [including 12 identified bots]).
Forum time: 23:11 CEST (Europe/Vienna)

We must be careful not to confuse data with the abstractions
we use to analyze them.    William James

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5