ANOVA fixed and random effects [General Statistics]
It's a food effect study where the subject takes the study drug under fasted conditions, 14-day washout, then takes study drug under fed conditions. The proposed is ANOVA model is to analyze log-transformed Cmax and AUClast with terms for treatment condition (Fasted and Fed) as a fixed effect and subject as a random effect.
Is this appropriate, and why or why not?
Compared to the standard 2x2 crossover study, what are the limitations of the above study design in terms of assessing inter- and intra-subject variability?
- ANOVA fixed and random effects Babe_Ruth 2019-02-08 18:32 [General Statistics]