Bioequivalence and Bioavailability Forum

Rules acc. to Health Canada [Outliers]

posted by ElMaestro  – Denmark, 2019-02-06 13:20 (1507 d 10:34 ago) – Posting: # 19881
Views: 6,119

Hi Shuanghe,

wouldn't you remove subject (sing.) with the highest absolute magnitude of studentised residual first, and then re-residual them all (having the first subject removed) before considering removal of the next?
I would do that, to perpetuate the thinking behind removal of calibrators that is widely used in bioanalytics.
It is the same kind of apples and pears

Complete thread:

• Rules acc. to Health Canada Helmut 2019-02-05 15:04 
  • Rules acc. to Health Canada ElMaestro 2019-02-05 15:30
    • Rules acc. to Health Canada Helmut 2019-02-05 16:24
      • Rules acc. to Health Canada ElMaestro 2019-02-05 17:33
  • Rules acc. to Health Canada Ohlbe 2019-02-05 15:54
    • Rules acc. to Health Canada Helmut 2019-02-05 17:52
  • for either the test or reference product? mittyri 2019-02-05 15:58
    • Discordant outliers Helmut 2019-02-05 17:42
  • Rules acc. to Health Canada Shuanghe 2019-02-06 11:48
    • Rules acc. to Health CanadaElMaestro 2019-02-06 12:20
      • ESD? mittyri 2019-02-06 14:04
        • ESD? ElMaestro 2019-02-06 18:12
  • Rules acc. to Health Canada zizou 2019-02-06 20:52
    • Great post! Helmut 2019-02-07 10:37