Bioequivalence and Bioavailability Forum

Hi BE-proff,

I just downloaded python and played around with it.
Syntatically it is not so hard, I think.

Below are some functions that will get you started. They execute just fine as a script on my computer (Win10). The functions use Simpson integrals and various constants that that you can play around with to achieve the combination of accuracy and speed that suits you. Note that I only made step 1-3, so I will leave it to you to put these into Potvin's equation.
They are in no way optimized so there's plenty of work to do still

import math


def GammaB(z):
 x=0.0
 dx=0.04
 integral=0.0
 di=10
 it=0
 while ((di>0.001) or  (x<8*z)):
  y =pow(x, z-1)*math.exp(-x)
  y1=pow(x+dx, z-1)*math.exp(-(x+dx))
  y2=pow(x+dx+dx, z-1)*math.exp(-(x+dx+dx))
  di= (dx/3)*(y+4*y1+y2)
  integral=integral +di
  x=x+dx+dx
  it+=1
 return(integral)


def DensityB(x, df):
 a=GammaB((df+1)/2.0 )
 b=math.sqrt(df*math.pi) * GammaB(df/2.0 )
 c=math.pow(1.0+x*x/df, -( (df+1) / 2.0))
 return(a*c/b)

def probtcum(df, t):
## note: for t>0 only, you can easily fix it for negative t
 x=0.0
 integral=0.5
 dx=0.5*t/100
 i=0
 while (i<100):
  y=DensityB(x, df)
  y1=DensityB(x+dx, df)
  y2=DensityB(x+dx+dx, df) 
  di = (dx/3)* (y+4*y1+y2)
  integral=integral+di
  x=x+dx+dx
  i+=1
     
 return(integral)

def critvalt(df, p):
##fix it yourself for p lowe than 0.5
 x=0.0
 integral=0.5
 dx=0.004
 while (integral<p):
  y=DensityB(x, df)
  y1=DensityB(x+dx, df)
  y2=DensityB(x+dx+dx, df) 
  di = (dx/3)* (y+4*y1+y2)
  integral=integral+di
  x=x+dx+dx
 ##aha!! now the solution is between x and x-2dx
 ##so we can just interpolate linearly
 a=di / (dx+dx)
 b=integral-a*x
 soln=(p-b) /a
 return(soln)


## in R, pt(df=5, 0.4) is 0.6471634
p=probtcum(5, 0.4)
print("probt cumul at df=5 for x=0.4", p, "should be", 0.6471634)

## in R, qt(df=11, 0.95) is 1.795885
q=critvalt(11, 0.95)
print("critt at df=11 and p=0.95=", q, "should be", 1.795885)





On my machine I get:

>>>
RESTART: [blahblah]
probt cumul at df=5 for x=0.4 0.6471629404086429 should be 0.6471634
critt at df=11 and p=0.95= 1.7958969293454883 should be 1.795885
>>>