blackwhite [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2019-02-04 14:34 (662 d 14:40 ago) – Posting: # 19862
Views: 4,173

Hi Nastia,

» […] By def Ctrough occurs at the end of dosing interval... I give up... It is impossible to distinguish!

Veto!
Look up trough in an English dictionary. A kind of minimum, right? The minimum (hence in the textbooks “Cmin”) can occur anywhere in the profile. If you have no lag-time the chance to observe it at the beginning and the end is 50% each (by definition).
I’m fine with the term Cτ,ss cause it is unambigous. IMHO, the term Ctrough shouldn’t be used at all.


Définissez les termes, vous dis-je, ou jamais nous ne nous entendrons.

Define your terms, you will permit me again to say, or we shall never understand one another.
Voltaire (Miracles, 1764)


Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,215 posts in 4,427 threads, 1,482 registered users;
online 12 (0 registered, 12 guests [including 8 identified bots]).
Forum time: Saturday 05:14 UTC (Europe/Vienna)

Science may be described as the art of systematic over-simplification –
the art of discerning what we may with advantage omit.    Karl R. Popper

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5