Log in
RegisterIs Cmin an atavism or not? [NCA / SHAM]
Dear all!
I searched through the forum and found plenty of themes dedicated to the difference between Cmin and Ctrough (Ctau). I thought that in the battle Cmin vs Ctrough, Ctrough was the winner. So that in the calculation of fluctuation (Peak-to-trough) and swing as well. According to wikipedia pharmacokinetics, for example, Cmin is Ctrough (was happy to see Helmut's graph there).
I finally upgraded to PHX/WNL 8.1 and see in the output the both versions of calculation: swing and swing_tau, Fluctuation and Fluctuation_tau. Some may think that PHX/WNL wants to show tollerance and include everyone's points of view... But, finally, what parameters should we include in the report according to official regulator's point of view? Or it depends on whether reference is IR or MR (see here)?
I searched through the forum and found plenty of themes dedicated to the difference between Cmin and Ctrough (Ctau). I thought that in the battle Cmin vs Ctrough, Ctrough was the winner. So that in the calculation of fluctuation (Peak-to-trough) and swing as well. According to wikipedia pharmacokinetics, for example, Cmin is Ctrough (was happy to see Helmut's graph there).
I finally upgraded to PHX/WNL 8.1 and see in the output the both versions of calculation: swing and swing_tau, Fluctuation and Fluctuation_tau. Some may think that PHX/WNL wants to show tollerance and include everyone's points of view... But, finally, what parameters should we include in the report according to official regulator's point of view? Or it depends on whether reference is IR or MR (see here)?
—
"Being in minority, even a minority of one, did not make you mad"
"Being in minority, even a minority of one, did not make you mad"
Complete thread:
- Steady state: Cmin / PTF Helmut 2011-03-08 15:30 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Steady state: Cmin / PTF SDavis 2012-02-06 14:00
- Steady state: Cmin / PTF Helmut 2012-02-06 14:24
- Is Cmin an atavism or not?Astea 2019-02-03 22:25
- Originators | generics (Cmin | Cτ) Helmut 2019-02-04 13:18
- Down with Big Brother Astea 2019-02-04 13:51
- Down with Big Brother Helmut 2019-02-04 14:43
- thoughtcrime Astea 2019-02-04 15:13
- blackwhite Helmut 2019-02-04 15:34
- animal farm Astea 2019-02-04 15:53
- blackwhite Helmut 2019-02-04 15:34
- thoughtcrime Astea 2019-02-04 15:13
- Down with Big Brother Helmut 2019-02-04 14:43
- Down with Big Brother Astea 2019-02-04 13:51
- Originators | generics (Cmin | Cτ) Helmut 2019-02-04 13:18
- Is Cmin an atavism or not?Astea 2019-02-03 22:25
- Steady state: Cmin / PTF Helmut 2012-02-06 14:24
- Steady state: Cmin / PTF SDavis 2012-02-06 14:00
Ing. Helmut Schütz