Bioequivalence and Bioavailability Forum

Hellobi ,

and thanks for helping towards an understanding.

I am a bit confused, what is ln[T] in your terminology?
Is it individual measurements, or effects form the b-vector or is it the average on the ln scale?
And what is the starting point for this?

Also, residuals -once a linear model has been fit to the least squares criterion- sum to zero, right? I got confused when you went from step 4 to 5.

❝ The Model Residual is the variance for the difference of LSMeans between Ln[T] and Ln[R].

Why?
I would think it is the plain uncertainty for an (within-) effect estimate in the b vector when we talk crossovers. Multiply by two and you have the variance of the difference or something like that.